The H2020-ICT10 project SOPHIA – Socio-physical Interaction Skills for Cooperative Human-Robot Systems in Agile Production – aims to create a new generation of core robotic technologies for socially cooperative human-robot systems. The objectives are to achieve a reconfigurable and resource-efficient production and improve human comfort and trust in automation, in hybrid human-plus-robot manufacturing environments. SOPHIA core intelligence will enable timely, natural, and human-in-command interactions between humans and robots on both social and physical levels, representing the new concept of socio-physical interaction. Additionally, the design and development of novel under-actuated wearable exoskeletons and collaborative robots with high payload and advanced loco-manipulation capacities are central to the mechatronics developments of the SOPHIA project. SOPHIA has a clear focus on standardization of its advanced technologies at a European level. It includes a large network of Digital Innovation Hubs for agile manufacturing (Trinity, DIH2, Flanders Make, DIH Umbria) and healthcare (DIHero) to ensure that its core technologies are “compliant by design” to standards in the field of human-robot interaction and collaboration.